Our group's resarch interests lie at the nexus of micro/nanoengineering, biophysics, biology, and biotechnology. Specifically, we focus on developing integrated, technology and biology based translational approaches to address critical challenges in human immune and neurological diseases. We integrate micro/nanoengineering tools and systems biology methods with new discoveries of mechanobiology, epigenetics, and classic signaling networks to provide transformative diagnostic and therapeutic solutions targeting immune and neurological diseases. We are also interested in developing novel synthetic biomimetic tools and platforms for understanding cancer biology, prevention, early detection, diagnosis, and treatment. (for details, please read our Research
; also see Mechanical Engineering Annual Reports highlighting our research, Y2010-2011 Report
, Y2012-2013 Report
, Y2014-2015 Report
Meet the lab: (front row, left to right) Shinuo Weng, Yue Shao, Xufeng Xue, Zida Li, and Yi Zheng; (back row, left to right) Zeta Yu, Koh Meng Aw Yong, Jianping Fu, Jianming Sang, and Xiang Li.
( (see Members)
Supported by the SURE program, mechanical engineering undergraduate student Huijiao Guan is working in Dr. Fu's lab on an integrated microfluidic system for functional phenotyping of patient immune cells.
Video recorded for our MCubed sponsored project, "Microfluidic systems immunology for transformative diagnostics for infants". Collaborative interdisciplinary team science to address complex clinical challenges. Our collaborators: Katsuo Kurabayashi, Timothy T. Cornell, and Thomas P. Shanley. (for details, please read our Research)
06/13/2016: Congratulations to Zeta! His manuscript on developing the vacuum-pressure accelerated movement (V-PAM) technology for accelerating biofluid filling in complex microfluidic networks is accepted by Small. (see Publications)
05/30/2016: Congratulations to Shinuo and Yue! Their manuscript on single-cell mechanical homeostasis is just published by Nature Materials. (see Publications)
05/23/2016: IBBL alumnus Prof. Weiqiang Chen has won the American Heart Association Scientist Development Award!
05/17/2016: Fu's research featured as cover story of two journals.
05/04/2016: Congratulations to Zida! His manuscript on developing a miniaturized device for precise measurements of dynamic blood clot retraction forces is accepted by Small. (see Publications)
03/02/2016: Congratulations to Yue! He was selected to receive the Rackham Predoctoral Fellowship. (see Student Awards)
02/29/2016: Congratulations to Yubing! His PhD thesis dissertation has been chosen for Honorable Mention for the Rackham Graduate School’s 2015 ProQuest Distinguished Dissertation Awards. (see Student Awards)
02/27/2016: Congratulations to Shinuo! She was selected for the 2016 Ivor K. McIvor Award. (see Student Awards)
01/29/2016: Congratulations to Raymond and other co-authors! His manuscript on developing a microfluidic elasticity microcytometer for multiparametric biomechanical and biochemical phenotypic profiling of live single cancer cells is accepted by Small. (see Publications)
01/26/2016: Congratulations to Yi! His manuscript on a microengineered 3D biomimetic model to study leukemic cell induced bone marrow angiogenesis is accepted by Advanced Healthcare Materials. (see Publications)
11/05/2015: 2014-2015 Mechanical Engineering Annual Report released. Our microfluidic systems immunology research is highlighted! (see Y2014-2015 Report)
10/28/2015: Our collaborative research with Dr. Deborah L. Gumucio's lab is published in Stem Cell Report! (see Publications)
07/09/2015: Congratulations to Xiang! His manuscript on a desktop aligner for multilayer assembly of PDMS-based microfluidic devices is accepted by Review of Scientific Instruments. (see Publications)
Two bubble acoustic tweezing cytometry for biomechanical probing and stimulation of cells
Di Chen, et al.
Biophysical Journal, vol. 108, pp. 32-42, 2015. [PDF]
Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes
Xiang Li, Weiqiang Chen, Guangyu Liu, Wei Lu, and Jianping Fu
Lab on a Chip, vol. 14, pp. 2565-2575, 2014. [PDF | Supplemental Materials]
Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
Yubing Sun, et al.
Nature Materials, vol. 13, pp. 599-604, 2014. [PDF | Supplemental Materials]
Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood
Bo-Ram Oh, et al.
ACS Nano, vol. 8, pp. 2667–2676, 2014. [PDF | Supplemental Materials]
Architecture of F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction
Yue Shao, Jennifer M. Mann, Weiqiang Chen, and Jianping Fu
Integrative Biology, vol. 6, pp. 300-311, 2014. [PDF | Supplemental Materials]