Our group's interests lie at the nexus of micro/nanoengineering, biophysics, biology, and biotechnology. Currently, we focus on developing integrated systems for high throughput quantitative micro/nanoscale analysis of molecular and cellular functions. Specifically, we are developing integrated techniques to investigate biological entities (from nanoscale biomolecules to micron-sized mammalian cells) confined in micro/nanofluidic environments. We study molecular and cellular interactions with these micro/nanofluidic structures and explore the opportunity of using these micro/nanofluidic devices for ultra-sensitive biosensing and detection as well as for efficient biosample preparation. We are also interested in developing synthetic micro/nanoscale cellular microenvironment to direct cellular behaviors, and further employing them to identify the extrinsic physical factors and their downstream signaling pathways that regulate cell functions. (for details, please read our Research
Meet the lab (from left to right):
Jianping Fu, Zeta Yu, Weiqiang Chen, Xiang Li, Feng Zhang, Takahiro Nakashima, Shinuo Weng, Yue Shao, Yubing Sun, and Raymond Lam (see Members)
05/21/2013: Congratulations to Weiqiang, for winning the Best Student Seminar Speaker Award for the MBSTP Seminar Series!
03/20/2013: Fu's research featured as front cover story of three journals. (see UM ME News)
02/08/2013: Congratulations to Weiqiang! He has just won the UM CoE Richard F. & Eleanor A. Towner Prize for Distinguished Academic Achievement.
02/06/2013: Congratulations to Weiqiang and Yue for their great achievements in the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB2013)! They have won the Outstanding Poster Award (Weiqiang) and the Outstanding Student Podium Talk Award (Yue) from the conference.
02/05/2013: Congratulations to Yubing! His paper is selected as the front cover story for 2013, Issue 3 of Integrative Biology. (see Publications)
02/01/2013: Rounding up rare cells: Engineers and doctors connect to solve major diagnosis challenges. (see UM Engineering News)
01/22/2013: Congratulations to Weiqiang! His Small and ACS Nano papers are both selected as the front cover story. (see Publications)
12/15/2012: Congratulations to Yubing on our Integrative Biology paper!
12/03/2012: Congratulations to Weiqiang on our Advanced Healthcare Materials paper!
11/29/2012: Congratulations to Weiqiang on our ACS Nano paper!
(Note: this paper is highlighted by UM Homepage, UM News Service, UM Health System, UM ME Dept. News, C&EN Online Story, ACS Nano Podcast, Medical News Today, MediLexicon, ScienceDaily, PhysOrg, and Bio-Medicine)
Mechanobiology: A new frontier for human pluripotent stem cells
Yubing Sun and Jianping Fu
Integrative Biology, in press, 2013. (DOI: 10.1039/C2IB20256E) (Download: PDF)
Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells
Weiqiang Chen, et al.
Advanced Healthcare Materials, in press, 2013. (DOI: 10.1002/adhm.201200378) (Download: PDF)
Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies
Weiqiang Chen, et al.
ACS Nano, vol. 7, pp. 566-575, 2013. (Download: PDF)
Live-cell subcellular measurement of cell stiffness using a microengineered stretchable micropost array membrane
Raymond Hiu-Wai Lam, et al.
Integrative Biology, vol. 4, pp. 1289-1298, 2012. (Download: PDF)