Our group's resarch interests lie at the nexus of bioengineering, biophysics, and biology. Specifically, we focus on developing integrated, technology and biology based translational approaches to address critical challenges in human immune and neurological diseases. We integrate bioengineering tools and systems biology methods with new discoveries of mechanobiology, epigenetics, and classic signaling networks to provide transformative diagnostic and therapeutic solutions targeting immune and neurological diseases. We are also interested in developing novel synthetic biomimetic tools and platforms for understanding human development and cancer biology. (for details, please read our Research
; also see Mechanical Engineering Annual Reports highlighting our research, Y2010-2011 Report
, Y2012-2013 Report
, Y2014-2015 Report
Meet the lab: (first row, from left to right): Yi Zheng, Zida Li, Sajedeh Esfahani; (second row, from left to right) Zimo Yang, Yue Shao, Zeta Yu; (third row, from left to right) Xufeng Xue, Jianping Fu; (fourth row, from left to right) Chun-Yen Sung, Shinuo Weng, and Jianming Sang.
( (see Members)
Supported by the SURE program, mechanical engineering undergraduate student Huijiao Guan is working in Dr. Fu's lab on an integrated microfluidic system for functional phenotyping of patient immune cells.
Video recorded for our MCubed sponsored project, "Microfluidic systems immunology for transformative diagnostics for infants". Collaborative interdisciplinary team science to address complex clinical challenges. Our collaborators: Katsuo Kurabayashi, Timothy T. Cornell, and Thomas P. Shanley. (for details, please read our Research)
04/22/2017: Congratulations to Yi! His manuscript on using a microfluidic angiogenesis platform to study Notch signaling is just accepted by Lab on a Chip. (see Publications)
04/21/2017: Congratulations to Xufeng! His manuscript on using the acoustic tweezing cytometry for enhancing osteogenesis of human mesenchymal stem cells is just accepted by Biomaterials. (see Publications)
04/12/2017: Our group's cell mechanics research has been highlighted in the Technology Feature by Nature. (link)
12/14/2016: Yue has successfully defended his Ph.D. thesis. Congratulations, Dr. Shao! (see Group Photos)
12/12/2016: Congratulations to Yue! His manuscript on in vitro modeling of amniogenesis using human pluripotent stem cells is just published by Nature Materials. (see Group Photos and Publications)
12/08/2016: Undergraduate student Parker Haffey working at IBBL won the Best Poster Award for the RISE program! (see Group Photos)
11/17/2016: Shinuo has successfully defended her Ph.D. thesis. Congratulations, Dr. Weng! (see Group Photos)
11/11/2016: Congratulations to Yue! He just won the Richard and Eleanor Towner Prize for Outstanding Ph.D. Research. (see Student Awards, Group Photos, and Mechanical Engineering News)
11/10/2016: Fu's paper published to Nature Materials.
10/04/2016: Li receives Baxter Young Investigator Award.
09/25/2016: Fu's research featured as cover story of two Small issues.
08/19/2016: Congratulations to Zida! He was selected to receive the Baxter Young Investigator Award (Tier 1). (see Student Awards)
06/13/2016: Congratulations to Zeta! His manuscript on developing the vacuum-pressure accelerated movement (V-PAM) technology for accelerating biofluid filling in complex microfluidic networks is accepted by Small. (see Publications)
05/30/2016: Congratulations to Shinuo and Yue! Their manuscript on single-cell mechanical homeostasis is just published by Nature Materials. (see Publications)
05/23/2016: IBBL alumnus Prof. Weiqiang Chen has won the American Heart Association Scientist Development Award!
05/17/2016: Fu's research featured as cover story of two journals.
05/04/2016: Congratulations to Zida! His manuscript on developing a miniaturized device for precise measurements of dynamic blood clot retraction forces is accepted by Small. (see Publications)
03/02/2016: Congratulations to Yue! He was selected to receive the Rackham Predoctoral Fellowship. (see Student Awards)
Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche
Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous molecular expression and metastatic characteristics
Yue Shao, et al.
Nature Materials, vol. 16, pp. 419-425, 2017. [PDF | Supplemental Materials]
Weiqiang Chen, et al.
, vol. 16, 614, 2016. [PDF
A miniaturized hemoretractometer for blood clot retraction testing
Zida Li, Xiang Li, Brendan McCracken, Yue Shao, Kevin Ward, and Jianping Fu
, vol. 12, pp. 3926-3934, 2016. [PDF | Supplemental Materials
Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis
Shinuo Weng, Yue Shao, Weiqiang Chen, and Jianping Fu
, vol. 15, pp. 961-967, 2016. [PDF
| Supplemental Materials
Multiparametric biomechanical and biochemical phenotypic profiling of single cancer cells using elasticity microcytometer
Shuhuan Hu, Guangyu Liu, Weiqiang Chen, Xiang Li, Wei Lu, Raymond H. W. Lam, and Jianping Fu
, vol. 12, pp. 2300-2311, 2016. [PDF
| Supplemental Materials
Angiogenesis in liquid tumors: An in-vitro assay for leukemic cell induced bone marrow angiogenesis
Yi Zheng, Yubing Sun, Xinwei Yu, Yue Shao, Ping Zhang, Guohao Dai, and Jianping Fu
Advanced Healthcare Materials
, vol. 5, pp. 1014-1024, 2016. [PDF
| Supplemental Materials