Our group's interests lie at the nexus of micro/nanoengineering, biophysics, biology, and biotechnology. Currently, we focus on developing integrated systems for high throughput quantitative micro/nanoscale analysis of molecular and cellular functions. Specifically, we are developing integrated techniques to investigate biological entities (from nanoscale biomolecules to micron-sized mammalian cells) confined in micro/nanofluidic environments. We study molecular and cellular interactions with these micro/nanofluidic structures and explore the opportunity of using these micro/nanofluidic devices for ultra-sensitive biosensing and detection as well as for efficient biosample preparation. We are also interested in developing synthetic micro/nanoscale cellular microenvironment to direct cellular behaviors, and further employing them to identify the extrinsic physical factors and their downstream signaling pathways that regulate cell functions. (for details, please read our Research
Meet the lab:
(front row) Koh Meng Aw Yong, Zeta Yu, Jianping Fu, and Raymond Lam;
Jianming Sang, Xiang Li, Shinuo Weng, Zida Li, Ping Zhang, Weiqiang Chen, Yue Shao, and Yubing Sun. (see Members)
Supported by the SURE program, mechanical engineering undergraduate student Huijiao Guan is working in Dr. Fu's lab on an integrated microfluidic system for functional phenotyping of patient immune cells.
Video recorded for our MCubed sponsored project, "Microfluidic systems immunology for transformative diagnostics for infants". Collaborative interdisciplinary team science to address complex clinical challenges. Our collaborators: Katsuo Kurabayashi, Timothy T. Cornell, and Thomas P. Shanley. (for details, please read our Research)
03/04/2014: Congratulations to Yubing! His manuscript was just accepted in Nature Materials! (see Publications)
01/28/2014: Dr. Fu was selected for Mechanical Engineering Department Outstanding Achievement Award!
01/14/2014: Weiqiang had just won the Chinese Government Award for Outstanding Self-Financed Students Abroad!
12/31/2013: Congratulations to Yue! He was just awarded the Keystone Symposia Future of Science Fund Scholarship.
12/26/2013: Congratulations to Yue! His manuscript was just accepted in Integrative Biology! (see Publications)
11/16/2013: Congratulations to Weiqiang! He has just won the UM CoE Richard F. & Eleanor A. Towner Prize for Outstanding Ph.D. Research.
10/18/2013: Congratulations to Xiang for passing the Ph.D. qualify exam!
10/14/2013: Congratulations to Yue on his review paper accepted in Advanced Materials! (see Publications)
08/05/2013: Congratulations to Weiqiang! He has been just awarded the Baxter Young Investigator Award as well as the UM Rackham Graduate Student Research Grant!
07/10/2013: Congratulations to Weiqiang! He has been just awarded the American Heart Association Predoctoral Fellowship!
06/28/2013: Congratulations to Yubing on our collaborative paper published in Scientific Reports with Dr. Cheri Deng's lab! (see Publications)
05/21/2013: Congratulations to Weiqiang, for winning the Best Student Seminar Speaker Award for the MBSTP Seminar Series!
03/20/2013: Fu's research featured as front cover story of three journals. (see UM ME News)
02/08/2013: Congratulations to Weiqiang! He has just won the UM CoE Richard F. & Eleanor A. Towner Prize for Distinguished Academic Achievement.
02/06/2013: Congratulations to Weiqiang and Yue for their great achievements in the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB2013)! They have won the Outstanding Poster Award (Weiqiang) and the Outstanding Student Podium Talk Award (Yue) from the conference.
Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
Yubing Sun, et al.
Nature Materials, in press, 2014.
Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood
Bo-Ram Oh, et al.
ACS Nano, in press, 2014. (DOI: 10.1021/nn406370u) [PDF]
Architecture of F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction
Yue Shao, Jennifer M. Mann, Weiqiang Chen, and Jianping Fu
Integrative Biology, vol. 6, pp. 300-311, 2014. [PDF]
Integrating micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: A materials perspective
Yue Shao, and Jianping Fu
Advanced Materials, vol. 26, pp. 1494-1533, 2014. [PDF]
Acoustic tweezing cytometry for live-cell subcellular control of intracellular cytoskeleton contractility
Zhenzhen Fan, Yubing Sun, Di Chen, Donald Tay, Weiqiang Chen, Cheri X. Deng, and Jianping Fu
Scientific Reports, vol. 3, 2176, 2013. [PDF]